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Most downloaded review Q1 2009: Target discovery from data mining approaches

The most downloaded review article from Drug Discovery Today from the first quarter of 2009 deals with the topic of target discovery from the informatics perspective. It would be difficult to overstate...

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Drug Discovery Today Citation Classic: The growing impact of click chemistry...

Welcome to the first article in Drug Discovery Today Citation Classics. I would say that it is very hard to predict what articles will make citation classic articles, but I suppose that having a Nobel...

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Drug Discovery Today: highlighted review. ‘Metabolite-likeness’ as a...

This highlighted review from Drug Discovery Today by Dobson, Patel and Kell outlines how "metabolite-likeness" in an analogous manner to "drug-likeness" and "lead-likeness" can be used to improve the...

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Drug discovery in the era of Facebook—new tools for scientific networking

This article is involved with the impact that social networking is beginning to make on drug discovery process. While bioinformaticsand chemoinformatics underpin research at a scientific level, rapid...

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Medicinal chemistry strategies in follow-on drug discovery

This article was the most downloaded article in the period Q2 2009. A common theme appears with many of our most popular articles in that they frequently relate to medicinal chemistry strategy or...

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Transforming fragments into candidates: small becomes big in medicinal chemistry

Again, medicinal chemistry features highly in our "Most downloaded" spot. This time we feature the extremely hot topic of fragment-based drug discovery, from some of the most influential experts, based...

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The impact of aromatic ring count on compound developability – are too many...

The content of the most downloaded article in Q4 2009 deals with the impact of the number of aromatic rings on the ability to deliver quality compounds for drug development. This information and...

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Visualizing the drug target landscape

This article, by Stephen J. Campbell, Anna Gaulton, Jason Marshall, Dmitri Bichko, Sid Martin, Cory Brouwer1 and Lee Harland was the most downloaded article of Q1 2010. It deals with tools to integrate...

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Pharmacophore modeling and applications in drug discovery: challenges and...

The most downloaded article from Drug Discovery Today in Q2 2010 was by Sheng-Yong Yang and deals with the application of pharmacophore modeling to drug discovery.

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Getting physical in drug discovery: a contemporary perspective on solubility...

The physical properties of drug molecules are frequently identified as a shortcoming of drugs in development. This article, the most highly-downloaded of Q3 2010, proposes a novel approach to the...

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Cancer nanotechnology: application of nanotechnology in cancer therapy

In this article, the most downloaded article of Q4 2010, Ranjita Misra, Sarbari Acharya and Sanjeeb K. Sahoo discuss the applications of nanotechnology to the treatment of cancer

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The graphical representation of ADME-related molecule properties for...

In this article, the most downloaded of Q1 2011, Timothy J. Ritchie, Peter Ertl and Richard Lewis review various approaches that have been used to represent molecule properties graphically in the...

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Learning lessons from drugs that haverecently entered the market

In this article, the most downloaded of Q2 2011, Simon Teague outlines that the key determinants for success in drug discovery can be defined by studying recently launched drugs.

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Drug discovery in the next decade:innovation needed ASAP

The pharmaceutical sector, a cornerstone of the healthcare industry, is undergoing dramaticchange, primarily caused by reduced output of new medicines from research and development(R&D)...

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What makes a good drug target?

In this article, Isabella Gashaw , Peter Ellinghaus, Anette Sommer and Khusru Asadullah discuss those factors that differentiate good drug targets from poor or the unusable.

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Getting the most out of your IP – patent management along its life cycle

We discover that successful patent portfolio management is rooted in managing the patents along their life cycles.

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Peptide therapeutics: current statusand future directions

Here, the authors discuss the current status, strengths, and weaknesses of peptides as medicines and the emerging new opportunities in peptide drug design and development.

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